ALKALOIDS FROM PSYCHOTRIA-OLEOIDES WITH ACTIVITY ON GROWTH-HORMONE RELEASE

被引:44
作者
GUERITTEVOEGELEIN, F
SEVENET, T
PUSSET, J
ADELINE, MT
GILLET, B
BELOEIL, JC
GUENARD, D
POTIER, P
机构
[1] CNRS, INST CHIM SUBST NAT, F-91198 GIF SUR YVETTE, FRANCE
[2] CTR PAUL BROCA, INSERM, U159, F-75014 PARIS, FRANCE
来源
JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 07期
关键词
D O I
10.1021/np50085a012
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Bioactivity-guided purification of a crude alkaloid extract of Psychotria oleoides has afforded a new alkaloid, psycholeine [1], together with quadrigemine C [2], a tetrameric pyrrolidinoindoline compound of unknown stereochemistry. A comparison study of nmr and cd spectra of quadrigemine C and hodgkinsine [3], a trimeric pyrrolidinoindoline substance, led us to suggest the stereochemistry of quadrigemine C. The structure and configuration of psycholeine was determined by spectroscopic means and chemical correlation with quadrigemine C. Psycholeine interacts with somatostatin receptors and exhibits a somatostatin antagonistic activity on GH secretion by pituitary cells in primary culture.
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页码:923 / 930
页数:8
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