EFFECT OF ENALAPRIL ON INTRACELLULAR RESISTANCE AND CONDUCTION-VELOCITY IN RAT VENTRICULAR MUSCLE

被引：8

作者：

DEMELLO, WC ^{[1
]}

CRESPO, MJ ^{[1
]}

ALTIERI, P ^{[1
]}

机构：

[1] SCH MED SAN JUAN, CARDIOVASC LAB, SAN JUAN, PR 00936 USA

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1993年 / 22卷 / 02期

关键词：

ENALAPRIL; CONDUCTION VELOCITY; INTRACELLULAR RESISTANCE; HEART;

D O I：

10.1097/00005344-199308000-00014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of enalapril on the intracellular resistance (r(i)) and conduction velocity was investigated in isolated rat trabeculae. The results indicated a decline in the internal resistance of 35.5% (SE +/- 3.3) and an increase in conduction velocity of 58.7% (SE +/- 6.6). The action potential duration was not altered. but the resting potential was increased by 10.5 mV (SE +/- 4.4). Enalaprilat had no effect on r(i) probably because the molecule is a diacid and does not cross the cell membrane. These findings indicate that the renin-angiotensin system is involved in the modulation of cell communication in cardiac muscle and that the beneficial effect of the drug in patients with congestive heart failure is, in part, related to an improvement of electrical synchronization of heart cells.

引用

页码：259 / 263

页数：5

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