THE TOTAL ASYMMETRIC-SYNTHESIS OF HALICHOLACTONE AND NEOHALICHOLACTONE

被引：38

作者：

CRITCHER, DJ

CONNOLLY, S

WILLS, M

机构：

[1] UNIV BATH,SCH CHEM,BATH BA2 7AY,AVON,ENGLAND

[2] FISONS PLC,DIV PHARMACEUT,RES & DEV LABS,LOUGHBOROUGH LE11 0RH,LEICS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 21期

关键词：

D O I：

10.1016/0040-4039(95)00588-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Completion of the first total synthesis of the marine natural products Halicholactone and Neohalicholactone is reported. The key step is a moderately stereoselective coupling between a vinylic anion and an aldehyde. An unexpectedly slow desilylation due to the presence of a proximal hydroxy group is also reported.

引用

页码：3763 / 3766

页数：4

共 14 条

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