EFFECTS OF DIFFERENT TYPES OF ANTIAGING DIETARY RESTRICTIONS ON AGE-RELATED ATRIAL-NATRIURETIC-FACTOR CHANGES - AN IMMUNOCHEMICAL AND ULTRASTRUCTURAL-STUDY

被引：5

作者：

CAVALLINI, G ^{[1
]}

CLERICO, A ^{[1
]}

DELCHICCA, M ^{[1
]}

GORI, Z ^{[1
]}

BERGAMINI, E ^{[1
]}

机构：

[1] UNIV PISA,SCUOLA MED,IST PATOL GEN,I-56100 PISA,ITALY

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1995年 / 7卷 / 02期

关键词：

AGING; ATRIAL CARDIOCYTES; ATRIAL NATRIURETIC FACTOR; RAT;

D O I：

10.1007/BF03324300

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The effects of two types of anti-aging dietary restrictions restrictoins - 60% diet restriction (DR) and every-other-day feeding (intermittent feeding, IF) - on age-related changes in atrial natriuretic factor (ANF) metabolism were studied in male Sprague Dawley rats by standard radioimmunological procedures and transmission electron microscopy. Both diet restrictions decreased plasma ANP (atrial natriuretic peptide) levels significantly (12-month-old rats: ad libitum fed controls 96+/-17.3 pg/mL, IF 63+/-4.8 pg/mL, DR 74+/-14.4 pg/mL; 24-month-old rats: AL 109+/-6.3 pg/mL, IF 75+/-8.9 pg/mL, DR 65+/-9.1 pg/mL). Dietary restriction prevented the age-related increase in ANP concentration in both the right atrium (12-month-old rats: AL 0.25+/-0.033 mu g/mg, IF 0.22+/-0.023 mu g/mg, DR 0.30+/-0.044 mu g/mg; 24-month-old rats: AL 0.39+/-0.037 mu g/mg, IF 0.10+/-0.015 mu g/mg, DR 0.07+/-0.011 mu g/mg) and left atrium (12-month-old rats: AL 0.23+/-0.033 mu g/mg, IF 0.13+/-0.019 mu g/mg, DR 0.17+/-0.035 mu g/mg; 24-month-old rats: AL 0.44+/-0.037 mu g/mg, IF 0.07+/-0.009 mu g/mg, DR 0.07+/-0.011 mu g/mg). Endocrine cardiocytes of diet-restricted senescent rats could be readily distinguished ultrastructurally from cells of ad libitum fed controls due to a higher number of beta-atrial specific granules of lower electrondensity. In conclusion, anti-aging diet restriction regimens fully prevented the age-related increase in the hormone store in atrial tissue, and lowered plasma ANP levels.

引用

页码：117 / 122

页数：6

共 30 条

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