A NOVEL TYPE OF MYOSIN IMPLICATED IN SIGNALING BY RHO-FAMILY GTPASES

被引:147
作者
REINHARD, J
SCHEEL, AA
DIEKMANN, D
HALL, A
RUPPERT, C
BAHLER, M
机构
[1] MAX PLANCK GESELL,FRIEDRICH MIESCHER LAB,D-72076 TUBINGEN,GERMANY
[2] UNIV LONDON UNIV COLL,MRC,MOLEC CELL BIOL LAB,CRC ONCOGENE & SIGNAL TRANSDUCT GRP,LONDON WC1E 6BT,ENGLAND
[3] UNIV LONDON UNIV COLL,DEPT BIOCHEM,LONDON WC1E 6BT,ENGLAND
关键词
ACTIN; GTPASE-ACTIVATING PROTEIN; MYOSIN; RHO; ZINC BINDING;
D O I
10.1002/j.1460-2075.1995.tb07048.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A novel widely expressed type of myosin (fifth unconventional myosin from rat: myr 5) from rat tissues, defining a ninth class of myosins, was identified, The predicted amino acid sequence of myr 5 exhibits several features not found previously in myosins. The myosin head domain contains a unique N-terminal extension and an insertion of 120 amino acids at a postulated myosin-actin contact site, Nevertheless, myr 5 is able to bind actin filaments in an ATP-regulated manner, The head domain is followed by four putative light chain binding sites. The tail domain of myr 5 contains a region which coordinates two atoms of zinc followed by a region that stimulates GTP hydrolysis of members of the ras-related rho subfamily of small G-proteins. Myr 5 therefore provides the first direct link between rho GTPases which have been implicated in the regulation of actin organization and the actin cytoskeleton, It is also the first unconventional myosin for which a tail binding partner(s), namely members of the rho family, has been identified.
引用
收藏
页码:697 / 704
页数:8
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