POSTMORTEM EXAMINATION OF DOPAMINERGIC PARAMETERS IN ALZHEIMERS-DISEASE - RELATIONSHIP TO NONCOGNITIVE SYMPTOMS

被引：9

作者：

BIERER, LM

KNOTT, PJ

SCHMEIDLER, JM

MARIN, DB

RYAN, TM

HAROUTUNIAN, V

PUROHIT, DP

PERL, DP

MOHS, RC

DAVIS, KL

机构：

[1] MT SINAI SCH MED,DEPT BIOSTAT,NEW YORK,NY 10029

[2] MT SINAI SCH MED,DEPT PATHOL NEUROPATHOL,NEW YORK,NY 10029

来源：

PSYCHIATRY RESEARCH | 1993年 / 49卷 / 03期

关键词：

DEMENTIA; DEPRESSION; AGITATION; PSYCHOSIS; COGNITIVE IMPAIRMENT; TEMPORAL CORTEX; NEUROPATHOLOGY; HOMOVANILLIC ACID; DIHYDROXYPHENYLACETIC ACID;

D O I：

10.1016/0165-1781(93)90062-L

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Dopaminergic mechanisms have been implicated in depression, agitation, and psychosis--symptoms that are frequently observed in patients with Alzheimer's disease (AD). In a longitudinal study, 23 prospectively assessed AD patients underwent autopsies in which concentrations of dopamine, homovanillic acid, and dihydroxyphenylacetic acid were assayed in the temporal lobe (Brodmann areas 20 and 21). Data-reduction techniques were used to minimize the number of relationships tested. For this series of AD patients, no significant correlation was found between indices of dopaminergic neurotransmission and maximal severity of psychosis, depression, or agitation.

引用

页码：211 / 217

页数：7

共 23 条

[1]

COCCARO EF, 1990, AM J PSYCHIAT, V147, P1640

[2]

DAVIS KL, 1991, AM J PSYCHIAT, V148, P1474

[3] LATERALIZED TEMPORAL-LIMBIC DYSFUNCTION AND PSYCHOPATHOLOGY [J].