RECOGNITION OF DNA-SEQUENCES BY STRAND REPLACEMENT WITH POLYAMINO-OLIGONUCLEOTIDES

被引：62

作者：

SCHMID, N ^{[1
]}

BEHR, JP ^{[1
]}

机构：

[1] FAC PHARM STRASBOURG, CNRS, CHIM GENET LAB, F-67401 ILLKIRCH GRAFFENSTADEN, FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 09期

关键词：

D O I：

10.1016/0040-4039(95)00027-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modified 11-mer oligodeoxyribonucleotide 1* of sequence ATTG*AATG*TTT, containing two spermine residues linked to the C2 position of inosine (G*; 2-aminoinosine is guanosine) was synthesized. Its duplex 2.1* structure with the complementary strand 2 melted 25-15 degrees C higher than the natural 2.1 DNA, depending on the ionic composition of the medium. Furthermore, polyacrylamide gel electrophoresis showed 1* to be able to replace 1 from 2.1 in a physiologically relevant medium and some 30 degrees C below the melting temperature of 2.1

引用

页码：1447 / 1450

页数：4

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