DAILY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) IMPROVES MOOD IN DEPRESSION

被引：702

作者：

GEORGE, MS

WASSERMANN, EM

WILLIAMS, WA

CALLAHAN, A

KETTER, TA

BASSER, P

HALLETT, M

POST, RM

机构：

[1] MED UNIV S CAROLINA,DEPT PSYCHIAT RADIOL & NEUROL,CHARLESTON,SC 29425

[2] NIND,MED NEUROL BRANCH,HUMAN MOTOR CONTROL SECT,BETHESDA,MD 20897

[3] NIH,NCRR,BIOMED ENGN & INSTRUMENTAT PROGRAM,BETHESDA,MD 20897

[4] NIAA,BETHESDA,MD 20897

来源：

NEUROREPORT | 1995年 / 6卷 / 14期

关键词：

DEPRESSION; TRANSCRANIAL MAGNETIC STIMULATION; PREFRONTAL CORTEX; TREATMENTS; AFFECTIVE DISORDERS;

D O I：

10.1097/00001756-199510020-00008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CONVERGING evidence points to hypofunction of the left prefrontal cortex in depression. Repetitive transcranial magnetic stimulation (rTMS) activates neurons near the surface of the brain. We questioned whether daily left prefrontal rTMS might improve mood in depressed subjects and report a pilot study of such treatment in six highly medication-resistant depressed inpatients. Depression scores significantly improved for the group as a whole (Hamilton Depression Scores decreased from 23.8 +/- 4.2 (s.d.) at baseline to 17.5 +/- 8.4 after treatment; t = 3.03, 5DF, p = 0.02, two-tailed paired t-test). Two subjects showed robust mood improvement which occurred progressively over the course of several weeks. In one subject, depression symptoms completely remitted for the first time in 3 years. Daily left prefrontal rTMS appears to be safe, well tolerated and may alleviate depression.

引用

页码：1853 / 1856

页数：4

共 10 条

[1]

FLEISCHMANN A, 1994, EUR NEUROPSYCHOPHARM, V4, P449

[2]

George M.S., 1994, DEPRESSION, V2, P59, DOI DOI 10.1002/DEPR.3050020202

[3]

GEORGE MS, 1994, CONVULSIVE THER, V10, P251

[4]

GEORGE MS, 1994, DEC ABSTR AM C NEUR, P159