STUDIES ON THE PREPARATION OF ISOCARBACYCLIN INTERMEDIATES .1.

被引：3

作者：

KOGA, M ^{[1
]}

KAGEYAMA, H ^{[1
]}

TANAKA, T ^{[1
]}

FUJII, T ^{[1
]}

机构：

[1] TEIJIN LTD,CHEM MFG PLANT,IWAKUNI PHARMACEUT FACTORY,2-1 HINODE CHO,IWAKUNI,YAMAGUCHI 740,JAPAN

来源：

SYNTHETIC COMMUNICATIONS | 1994年 / 24卷 / 10期

关键词：

D O I：

10.1080/00397919408011749

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Studies on the practical method for trapping enolates generated from enone with organocopper reagent have been described. Instead of carcinogenic hexamethylphosphoric triamide (HMPA), N-methyl-2-pyrrolidone (NMP) has been found to be an effective additive for trapping the enolate.

引用

页码：1447 / 1455

页数：9

共 18 条

[1]

BAKER BJ, 1979, ANGEW CHEM INT EDIT, V18, P503

[2] MIXED CUPRATE REAGENTS OF TYPE R1R2CULI WHICH ALLOW SELECTIVE GROUP TRANSFER [J].

COREY, EJ ;

BEAMES, DJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (20) :7210-&

[3] SENSORY IRRITATION POTENTIAL OF SELECTED NASAL TUMORIGENS IN THE RAT [J].

GARDNER, RJ ;

BURGESS, BA ;

KENNEDY, GL .

FOOD AND CHEMICAL TOXICOLOGY, 1985, 23 (01) :87-92

[4]

GRYGLEWSKI RJ, 1985, PROSTACYCLIN CLIN TR

[5]

HAHL AR, 1983, TOXICOL APPL PHARM, V67, P200

[6]

HAZATO A, UNPUB TETRAHEDRON

[7]

LEWIS PL, 1981, CLIN PHARM PROSTAGLA

[8] AN EFFICIENT METHOD FOR THE PREPARATION OF HOMOALLYLIC ALCOHOL DERIVATIVES BY THE REACTION OF ALLYL IODIDE WITH CARBONYL-COMPOUNDS IN THE PRESENCE OF STANNOUS HALIDE [J].

MUKAIYAMA, T ;

HARADA, T ;

SHODA, SI .

CHEMISTRY LETTERS, 1980, (12) :1507-1510

[9] SUBSTITUTION OF HMPT BY THE CYCLIC UREA DMPU AS A COSOLVENT FOR HIGHLY REACTIVE NUCLEOPHILES AND BASES [J].

MUKHOPADHYAY, T ;

SEEBACH, D .

HELVETICA CHIMICA ACTA, 1982, 65 (01) :385-391

[10] ORGANIC-SYNTHESIS OF PROSTAGLANDINS - ADVANCING BIOLOGY [J].

NOYORI, R ;

SUZUKI, M .

SCIENCE, 1993, 259 (5091) :44-45

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