A SYNTHESIS OF MORPHINE-6-GLUCURONIDE

被引：18

作者：

LACY, C

SAINSBURY, M

机构：

[1] School of Chemistry, University of Bath, Bath, BA2 7AY, Claverton Down

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 22期

关键词：

D O I：

10.1016/0040-4039(95)00649-W

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical synthesis of morphine-6-glucuronide from 3-acetylmorphine and methyl 2-alpha-bromo-3,4,5-tri-O-acetylglucuronate is described. Similar syntheses of codeine-6-glucuronide, codeine-6-glucoside and morphine-6-glucoside are also documented

引用

页码：3949 / 3950

页数：2

共 8 条

[1] SYNTHESIS OF MORPHINE-6-GLUCURONIDE VIA A HIGHLY SELECTIVE ENZYME-CATALYZED HYDROLYSIS REACTION [J].

BROWN, RT ;

CARTER, NE ;

SCHEINMANN, F ;

TURNER, NJ .

TETRAHEDRON LETTERS, 1995, 36 (07) :1117-1120

[2]

FRANCES B, 1992, J PHARMACOL EXP THER, V262, P25

[3] THE ANALGESIC ACTIVITY OF MORPHINE-6-GLUCURONIDE [J].

OSBORNE, R ;

THOMPSON, P ;

JOEL, S ;

TREW, D ;

PATEL, N ;

SLEVIN, M .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 34 (02) :130-138

[4]

SCHMIDT RR, 1981, SYNTHESIS-STUTTGART, P885

[5] PARTIAL SYNTHESIS OF SOME PHYSIOLOGICALLY RELEVANT GIBBERELLIN GLUCOSYL CONJUGATES [J].

SCHNEIDER, G ;

SEMBDNER, G ;

SCHREIBER, K ;

PHINNEY, BO .

TETRAHEDRON, 1989, 45 (05) :1355-1364

[6] GLYCOSYLIMIDATES .51. SYNTHESIS OF BETA-O-GLYCOSIDES USING ENOL ETHER AND IMIDATE DERIVED LEAVING GROUPS - EMPHASIS ON THE USE OF NITRILES AS A SOLVENT [J].

VANKAR, YD ;

VANKAR, PS ;

BEHRENDT, M ;

SCHMIDT, RR .

TETRAHEDRON, 1991, 47 (48) :9985-9992

[7]

YOSHIMURA H, 1968, CHEM PHARM BULL, V16, P2114

[8]

1993, PCTGB9201449 SALF UL

← 1 →