GLUTATHIONE-REDUCTASE FUNCTIONS AS VANADATE (V) REDUCTASE

被引：29

作者：

SHI, XL ^{[1
]}

DALAL, NS ^{[1
]}

机构：

[1] W VIRGINIA UNIV,DEPT CHEM,MORGANTOWN,WV 26505

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1990年 / 278卷 / 01期

关键词：

D O I：

10.1016/0003-9861(90)90262-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The oxidation of NADPH by vanadate(V) in the presence of glutathione reductase showed typical enzymatic kinetics. The oxidation was inhibited by N-ethylmaleimide, a glutathione reductase inhibitor. Superoxide dismutase had no significant effect on the oxidation, indicating noninvolvment of the superoxide radical. The vanadate(V) reduction was found to be a one-electron transfer process. These results suggest a new pathway for vanadate(V) metabolism and a new function of glutathione reductase. © 1990.

引用

页码：288 / 290

页数：3

共 23 条

[1]

Boyd D W, 1984, Adv Inorg Biochem, V6, P311

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