RESOLUTION OF (+1-)-PROPRANOLOL

被引：32

作者：

YOST, Y

HOLTZMAN, JL

机构：

[1] UNIV MINNESOTA, DEPT MED, MINNEAPOLIS, MN 55455 USA

[2] UNIV MINNESOTA, DEPT PHARMACOL, MINNEAPOLIS, MN 55455 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 09期

关键词：

Enantiomers—propranolol; resolving agents; Propranolol—racemic mixtures; resolution of enantiomers; (+)‐ and (‐)‐di‐(p‐toluoyl)tartaric acids used as resolving agents;

D O I：

10.1002/jps.2600680935

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two improvements in propranolol resolution were developed. Both the (+)‐ and (‐)‐di‐(p‐toluoyl)tartaric acids were used as the resolving agents. This procedure reduced the number of crystallizations needed to obtain a pure product. Furthermore, synthesis of the resolving agent was improved. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1181 / 1182

页数：2

共 6 条

[1]

BRECKENRIDGE A, 1974, CLIN PHARMACOL THER, V15, P424

[2] PHARMACOKINETICS OF DEXTRO PROPRANOLOL, LEVO PROPRANOLOL AND RACEMIC PROPRANOLOL IN MAN [J].