STRUCTURES OF PARALYTIC ACYLPOLYAMINES FROM THE SPIDER AGELENOPSIS-APERTA

被引：55

作者：

QUISTAD, GB ^{[1
]}

SUWANRUMPHA, S ^{[1
]}

JAREMA, MA ^{[1
]}

SHAPIRO, MJ ^{[1
]}

SKINNER, WS ^{[1
]}

JAMIESON, GC ^{[1
]}

LUI, A ^{[1
]}

FU, EW ^{[1
]}

机构：

[1] SANDOZ INS RES INST,E HANOVER,NJ 07935

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91431-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structures are given for five paralytic acylpolyamines from the venom of the funnel web spider, Agelenopsisaperta. The acyl moieties are derived from (3-indolyl)acetic acid, (4-hydroxy-3-indolyl)acetic acid, and 4-hydroxybenzoic acid. The polyamine portions of the toxins are novel. Three toxins (AG489, AG505, and AG452) contain 1, 5, 9, 13, 18, 22-hexaazadocosane which is unique as a natural polyamine because of its length and hydroxylation at the 5-aza position. The polyamine portions of two other α-agatoxins (AG488 and AG504) are unusual also, containing guanidinooxy moieties. © 1990.

引用

页码：51 / 56

页数：6

共 14 条

[1] 2 CLASSES OF CHANNEL-SPECIFIC TOXINS FROM FUNNEL WEB SPIDER VENOM [J].