THE P-LOOP - A COMMON MOTIF IN ATP-BINDING AND GTP-BINDING PROTEINS

被引：1887

作者：

SARASTE, M ^{[1
]}

SIBBALD, PR ^{[1
]}

WITTINGHOFER, A ^{[1
]}

机构：

[1] MAX PLANCK INST MED RES,BIOPHYS ABT,W-6900 HEIDELBERG 1,GERMANY

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 11期

关键词：

D O I：

10.1016/0968-0004(90)90281-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many ATP- and GTP-binding proteins have a phosphate-binding loop (P-loop), the primary structure of which typically consists of a glycine-rich sequence followed by a conserved lysine and a serine or threonine. The three-dimensional structures of several ATP- and GTP-binding proteins containing P-loops have now been solved. In this review current knowledge of P-loops is discussed with the additional aim of illustrating the fascinating relationship between protein sequence, structure and function. © 1990.

引用

页码：430 / 434

页数：5

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