STRUCTURE AND FUNCTION OF THE B-GENE AND D-GENE OF THE ACTINOBACILLUS-ACTINOMYCETEMCOMITANS LEUKOTOXIN COMPLEX

被引：55

作者：

LALLY, ET ^{[1
]}

GOLUB, EE ^{[1
]}

KIEBA, IR ^{[1
]}

TAICHMAN, NS ^{[1
]}

DECKER, S ^{[1
]}

BERTHOLD, P ^{[1
]}

GIBSON, CW ^{[1
]}

DEMUTH, DR ^{[1
]}

ROSENBLOOM, J ^{[1
]}

机构：

[1] UNIV PENN,SCH DENT MED,PERIODONT DIS RES CTR,PHILADELPHIA,PA 19104

来源：

MICROBIAL PATHOGENESIS | 1991年 / 11卷 / 02期

关键词：

ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; BACTERIAL TOXIN; VIRULENCE FACTOR; MOLECULAR CLONING; TRANSPORT PROTEIN; IMMUNOHISTOCHEMICAL LOCALIZATION;

D O I：

10.1016/0882-4010(91)90004-T

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Actinobacillus actinomycetemcomitans leukotoxin gene complex, consisting of four genes, has been cloned and the sequence of the AaLtC and AaLtA genes reported. The present paper details the sequences of the AaLtB and AaLtD genes which, like AaLtC and AaLtA, are also homologues of genes found in other cytolytic toxin complexes of several other Gram-negative bacterial pathogens. When tested in a recombinant expression system, the AaLtB and/or AaLtD genes are required for the translocation and insertion of the A. actinomycetemcomitans leukotoxin (AaLtA) into the cell membrane of Escherichia coli. © 1991.

引用

页码：111 / 121

页数：11

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