ANTITUMOR AGENTS .135. STRUCTURE AND STEREOCHEMISTRY OF POLACANDRIN, A NEW CYTOTOXIC TRITERPENE FROM POLANISIA-DODECANDRA

被引：19

作者：

SHI, Q

CHEN, K

FUJIOKA, T

KASHIWADA, Y

CHANG, JJ

KOZUKA, M

ESTES, JR

MCPHAIL, AT

MCPHAIL, DR

LEE, KH

机构：

[1] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

[2] UNIV N CAROLINA,SCH MED,ANIM MED LAB,CHAPEL HILL,NC 27599

[3] KYOTO PHARMACEUT UNIV,KYOTO 607,JAPAN

[4] UNIV OKLAHOMA,DEPT BOT,NORMAN,OK 73019

[5] DUKE UNIV,PAUL M GROSS CHEM LAB,DEPT CHEM,DURHAM,NC 27706

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 10期

关键词：

D O I：

10.1021/np50088a015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new dammarane triterpene, polacandrin [1], has been isolated from Polanisia dodecandra. The structure of 1 was established as 1beta,3alpha,12beta,25-tetrahydroxy-20(S),24(S)-epoxydammarane chemical and spectroscopic methods, which included the concerted application of a number of 2D nmr techniques that involved H-1-H-1 COSY, HETCOR, NOESY, and long-range HETCOR. Single-crystal X-my analysis of polacandrin pentahydrate verified the complete structure and stereochemistry. Polacandrin showed potent cytotoxicities against KB (ED50 = 0.60 mug/ml), P-388 (ED50 = 0.90 mug/ml), and RPMI-7951 (ED50 = 0.62 mug/ml) tumor cells.

引用

页码：1488 / 1497

页数：10

共 10 条

[1] TABLES OF BOND LENGTHS DETERMINED BY X-RAY AND NEUTRON-DIFFRACTION .1. BOND LENGTHS IN ORGANIC-COMPOUNDS [J].