BEHAVIORAL AND BIOCHEMICAL EFFECTS OF ACUTE CENTRAL METABOLIC INHIBITION - EFFECTS OF ACETYL-1-CARNITINE

被引：18

作者：

BLOKLAND, A ^{[1
]}

BOTHMER, J ^{[1
]}

HONIG, W ^{[1
]}

JOLLES, J ^{[1
]}

机构：

[1] UNIV LIMBURG,DEPT NEUROPSYCHOL & PSYCHOBIOL,POB 616,6200 MD MAASTRICHT,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 235卷 / 2-3期

关键词：

ACTYL-1-CARNITINE; HISTOTOXIC HYPOXIA; CYANIDE; SPATIAL LEARNING; PHOSPHOINOSITIDE METABOLISM;

D O I：

10.1016/0014-2999(93)90146-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present study we evaluated a new method to assess the behavioural and biochemical effects of a brief period of acute hypoxia in the brain. In this method, cyanide is injected into the lateral ventricles. Spatial navigation performance in a Morris task was found to be impaired 1 and 5 min after an i.c.v. injection of 5.0 mug cyanide but not after 2.5 mug cyanide. Increased rate of phosphatidic acid formation, reflecting increased phospholipase C activity, were observed after injection of 5.0 mug cyanide, indicating that energy-dependent phosphoinositide metabolism was affected. Chronic treatment with acetyl-1-carnitine attenuated the cyanide-induced behavioural deficit, but had no effect on energy-dependent phophoinositide metabolism. The results suggest that, in this model, acetyl-1-carnitine may act via free fatty acid metabolism, by increasing the reservoir of activated acyl groups which are involved in the reacylation of membrane phospholipids.

引用

页码：275 / 281

页数：7

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