USPIO-ENHANCED MR-IMAGING OF GLYCEROL-INDUCED ACUTE-RENAL-FAILURE IN THE RABBIT

被引：22

作者：

TRILLAUD, H ^{[1
]}

DEGREZE, P ^{[1
]}

COMBE, C ^{[1
]}

DEMINIERE, C ^{[1
]}

PALUSSIERE, J ^{[1
]}

BENDERBOUS, S ^{[1
]}

GRENIER, N ^{[1
]}

机构：

[1] HOP PELLEGRIN,SERV RADIOL,F-33076 BORDEAUX,FRANCE

来源：

MAGNETIC RESONANCE IMAGING | 1995年 / 13卷 / 02期

关键词：

CONTRAST MEDIA; KIDNEY MAGNETIC RESONANCE; KIDNEY BLOOD SUPPLY; GLYCEROL-INDUCED ACUTE RENAL FAILURE;

D O I：

10.1016/0730-725X(94)00114-I

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Enhanced-MR imaging in combination with ultrasmall superparamagnetic iron oxide (USPIO) was used in the glycerol-induced model of acute renal failure (ARF) in the rabbit to detect renal perfusion abnormalities. A control group (n = 5) and an ARF group (n = 5) were studied after intramuscular injection of glycerol (10 ml/kg) with T-2-weighted spin-echo sequence at 1.5 T and a 27 mu mol/kg IV dose of iron. The signal intensity (SI) was quantified in the cortex, the outer medulla (OM), and the inner medulla (IM). In control rabbits, the maximum SI decrease after USPIO injection was in the OM (76% +/- 3.6), as this is the region of maximal vascular density, then in the IM (73.4% +/- 2.9). In the glycerol group, SI loss in the OM (61% +/- 12.6) and the IM (45.2% +/- 16.24) was significant less than in the control group (p < .05). Pathology results showed fibrinous thrombus in the efferent arterioles and congestive aspect of the vasa recta in the medulla. We argue that a reduced medullary concentration of USPIO in the renal failure group is indicative of medullary hypoperfusion.

引用

页码：233 / 240

页数：8

共 19 条

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