ALTERED EFFECT OF INSULIN AND CATECHOLAMINES IN BROWN ADIPOSE-TISSUE OF COLD-ACCLIMATED RATS

被引：12

作者：

BEGINHEICK, N ^{[1
]}

NOLAND, I ^{[1
]}

DALPE, M ^{[1
]}

HEICK, HMC ^{[1
]}

机构：

[1] CHILDRENS HOSP EASTERN ONTARIO,ELEANOR M PATTERSON DEPT LAB MED,OTTAWA K1H 8L1,ONTARIO,CANADA

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1979年 / 57卷 / 03期

关键词：

D O I：

10.1139/y79-049

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Data are presented indicating that in brown adipose tissue (BAT) of cold-acclimated (CA), but not cold-exposed (CE) rats, there was an alteration in the relative response to catecholamines and insulin as evidenced by increased binding of alprenolol and decreased binding of insulin to plasma membrane enriched fractions. In addition, the stimulatory effect of insulin on glucose incorporation into glycogen and its inhibtory action on adenylate cyclase activity were both blunted in the CA tissues. It is proposed that shifts in the capacity of BAT to respond to catecholamines and insulin may be involved in the mechanism of cold acclimation.

引用

页码：320 / 324

页数：5

共 13 条

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