1,8-DINITROPYRENE - COMPARATIVE MUTAGENICITY IN CHINESE HAMSTER V79 AND CHO CELLS

被引：11

作者：

ODONOVAN, MR

机构：

[1] Boots Pharmaccuticals Research Department, Nottingham

来源：

MUTAGENESIS | 1990年 / 5卷 / 03期

关键词：

D O I：

10.1093/mutage/5.3.275

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

1,8-dinitropyrene (1,8-DNP) was clearly mutagenic at the hprt locus in CHO cells, but not detectably mutagenic in V79 cells, following a 3-h treatment period. Preliminary date indicate that CHO, but not V79, cells have measurable levels of N-acetyltransferase activity, and this may contribute to the differential sensitivity of the two cell lines to the mutagenicity of 1,8-DNP. © 1990 Oxford University Press.

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页码：275 / 277

页数：3

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