INTERACTION OF TAURINE WITH METHIONINE - INHIBITION OF MYOCARDIAL PHOSPHOLIPID METHYLTRANSFERASE

被引:66
作者
HAMAGUCHI, T
AZUMA, J
SCHAFFER, S
机构
[1] UNIV SO ALABAMA,SCH MED,DEPT PHARMACOL,MOBILE,AL 36688
[2] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 3,OSAKA,JAPAN
关键词
TAURINE; METHIONINE; CARDIAC WORK; SARCOLEMMAL NA+-CA2+ EXCHANGE; PHOSPHATIDYLETHANOLAMINE N-METHYLATION;
D O I
10.1097/00005344-199108000-00008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Perfusion of isolated, working rat heart with buffer containing 300-mu-M methionine in the presence of 2.5 U/L insulin led to a 15% decrease in cardiac work and a four-fold decrease in sarcolemmal Na+-Ca2+ exchange activity. These effects of methionine were largely prevented by inclusion of 10 mM taurine in the buffer supplemented with methionine and insulin. Taurine also reduced the extent of H-3-methyl group incorporation from radioactive methionine into myocardial phospholipids by approximately 45%. Assays of sarcolemmal phospholipid methyltransferase activity at catalytic sites I, II, and III revealed that taurine inhibited N-methylation activity approximately 30%. The data imply that the ability of taurine to modulate myocardial contraction and calcium transport may be related to taurine-mediated inhibition of phospholipid N-methylation.
引用
收藏
页码:224 / 230
页数:7
相关论文
共 36 条
[1]  
CHOVAN JP, 1979, BIOCHIM BIOPHYS ACTA, V551, P129, DOI 10.1016/0005-2736(79)90359-6
[2]  
CHOVAN JP, 1980, MOL PHARMACOL, V17, P295
[3]   SARCOLEMMAL PHOSPHATIDYLETHANOLAMINE N-METHYLATION IN DIABETIC CARDIOMYOPATHY [J].
GANGULY, PK ;
RICE, KM ;
PANAGIA, V ;
DHALLA, NS .
CIRCULATION RESEARCH, 1984, 55 (04) :504-512
[4]  
GUPTA MP, 1989, J PHARMACOL EXP THER, V249, P623
[5]  
GUPTA MP, 1988, J PHARMACOL EXP THER, V245, P664
[6]   STIMULATION OF NA+-CA-2+ EXCHANGE IN HEART SARCOLEMMA BY INSULIN [J].
GUPTA, MP ;
MAKINO, N ;
KHATTER, K ;
DHALLA, NS .
LIFE SCIENCES, 1986, 39 (12) :1077-1083
[7]  
HAMAGUCHI T, 1988, RES COMMUN CHEM PATH, V59, P21
[8]   REGULATION OF CALCIUM-TRANSPORT IN DRUG-INDUCED TAURINE-DEPLETED HEARTS [J].
HARADA, H ;
ALLO, S ;
VIYUOH, N ;
AZUMA, J ;
TAKAHASHI, K ;
SCHAFFER, SW .
BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 944 (02) :273-278
[9]   TAURINE DEFICIENCY AND DOXORUBICIN - INTERACTION WITH THE CARDIAC SARCOLEMMAL CALCIUM-PUMP [J].
HARADA, H ;
CUSACK, BJ ;
OLSON, RD ;
STROO, W ;
AZUMA, J ;
HAMAGUCHI, T ;
SCHAFFER, SW .
BIOCHEMICAL PHARMACOLOGY, 1990, 39 (04) :745-751
[10]   PHOSPHOLIPID-COMPOSITION AND TAURINE CONTENT OF SYNAPTOSOMES IN DEVELOPING RAT-BRAIN [J].
HUXTABLE, RJ ;
CROSSWELL, S ;
PARKER, D .
NEUROCHEMISTRY INTERNATIONAL, 1989, 15 (02) :233-238