GROWTH-RELATED LIPID PEROXIDATION IN TUMOR MICROSOMAL-MEMBRANES AND MITOCHONDRIA

被引：88

作者：

BARTOLI, GM ^{[1
]}

GALEOTTI, T ^{[1
]}

机构：

[1] CATHOLIC UNIV ROME,INST GEN PATHOL,I-00168 ROME,ITALY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 574卷 / 03期

关键词：

(Microsomal membrane; Mitochondria); Lipid peroxidation; Tumor growth;

D O I：

10.1016/0005-2760(79)90249-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microsomes and mitochondria isolated from Morris hepatomas 3924A (fast-growing) and 44 (slow-growing) and Ehrlich ascites tumour cells exhibit a NADPH-dependent peroxidation of endogenous lipids lower than that of the corresponding fractions from rat liver. Moreover, the O2-, and ascorbate-dependent lipid peroxidations are decreased in microsomes from the two Morris hepatomas. The peroxidative activity appears to be inversely related to the growth rate of the tumours. It is suggested that the low susceptibility of tumour membranes to peroxidative agents may be a factor responsible for the high mitotic activity of this tissue. © 1979.

引用

页码：537 / 541

页数：5

共 30 条

[1] EVIDENCE FOR SUPEROXIDE GENERATION BY NADPH-CYTOCHROME-C REDUCTASE OF RAT-LIVER MICROSOMES [J].

AUST, SD ;

ROERIG, DL ;

PEDERSON, TC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1972, 47 (05) :1133-&

[2] LIPID PEROXIDATION IN RAT TISSUE HOMOGENATES - INTERACTION OF IRON AND ASCORBIC ACID AS NORMAL CATALYTIC MECHANISM [J].

BARBER, AA .

LIPIDS, 1966, 1 (02) :146-&

[3] DIFFERENT CONTRIBUTION OF RAT-LIVER MICROSOMAL PIGMENTS IN FORMATION OF SUPEROXIDE ANIONS AND HYDROGEN-PEROXIDE DURING DEVELOPMENT [J].

BARTOLI, GM ;

GALEOTTI, T ;

PALOMBINI, G ;

PARISI, G ;

AZZI, A .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1977, 184 (01) :276-281

[4] RESPIRATORY ACTIVITY OF EHRLICH ASCITES TUMOR-CELL NUCLEI [J].

BARTOLI, GM ;

DANI, A ;

GALEOTTI, T ;

RUSSO, M ;

TERRANOVA, T .

ZEITSCHRIFT FUR KREBSFORSCHUNG UND KLINISCHE ONKOLOGIE, 1975, 83 (03) :223-231

[5]

BARTOLI GM, 1978, 12TH FEBS M DRESD

[6]

COLE BT, 1956, P SOC EXP BIOL MED, V93, P290, DOI 10.3181/00379727-93-22735

[7] CHOLESTEROL AND PHOSPHOLIPID COMPOSITION OF MITOCHONDRIA AND MICROSOMES ISOLATED FROM MORRIS HEPATOMA 5123 AND RAT-LIVER [J].

FEO, F ;

CANUTO, RA ;

BERTONE, G ;

GARCEA, R ;

PANI, P .

FEBS LETTERS, 1973, 33 (02) :229-232

[8] EFFECT OF CHOLESTEROL CONTENT ON SOME PHYSICAL AND FUNCTIONAL PROPERTIES OF MITOCHONDRIA ISOLATED FROM ADULT RAT-LIVER, FETAL LIVER, CHOLESTEROL-ENRICHED LIVER AND HEPATOMAS AH-130, 3924A AND 5123 [J].

FEO, F ;

CANUTO, RA ;

GARCEA, R ;

GABRIEL, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 413 (01) :116-134

[9] REOXIDATION OF CYTOPLASMIC REDUCING EQUIVALENTS IN EHRLICH ASCITES TUMOR CELLS [J].

GALEOTTI, T ;

AZZI, A ;

CHANCE, B .

BIOCHIMICA ET BIOPHYSICA ACTA, 1970, 197 (01) :11-+

[10]

GLUSHCHENKO N N, 1975, Biologicheskie Nauki (Moscow), V18, P51

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