EFFECT OF INTERFERON (IFN) ON REFRACTORY IDIOPATHIC THROMBOCYTOPENIC PURPURA - ADMINISTRATION OF 6 MILLION UNITS OF RECOMBINANT IFN ALPHA-2B

被引：9

作者：

ISHII, H ^{[1
]}

OH, H ^{[1
]}

UCHIDA, Y ^{[1
]}

NAKAMURA, H ^{[1
]}

ENDO, N ^{[1
]}

ASAI, T ^{[1
]}

YOSHIDA, S ^{[1
]}

机构：

[1] CHIBA UNIV,SCH MED,DEPT INTERNAL MED 2,1-8-1 INOHANA,CHUO KU,CHIBA 260,JAPAN

来源：

INTERNAL MEDICINE | 1992年 / 31卷 / 12期

关键词：

PLATELET COUNT; PLATELET-ASSOCIATED IGG; MEGAKARYOCYTE; PLATELET KINETICS; LYMPHOCYTE SUBSET ANALYSIS;

D O I：

10.2169/internalmedicine.31.1343

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Five patients (six courses) with refractory idiopathic thrombocytopenic purpura (ITP) were given 6 million units of recombinant interferon (IFN) alpha-2b in 12 doses to achieve an improved response rate compared to previous studies using 3 million units. From the initial IFN administration, the platelet count increased from a pre-treatment level of 20.7 +/- 17.7 x 10(3)/mul (mean +/- SD) and reached its first peak in weeks 2 or 3 of therapy (p < 0.05). In week 5, the platelet count made its second and maximum peak (66.5 +/- 57.9 x 10(3)/mul; p < 0.05). A relatively good response of the platelet count (an increase to > 50 x 10(3)/mul) was observed in three patients (four courses) out of five. These responses were not much faster or more improved than in previous reports, and a dose of 6 million units may be too large to treat some ITP patients. The platelet-associated IgG level showed a tendency to be reduced with IFN therapy. The mechanism for the increase of the platelet count may be the modification of platelet autoantibody production.

引用

页码：1343 / 1347

页数：5