VASCULARIZATION AND ENDOCHONDRAL BONE-DEVELOPMENT - CHANGES IN PLASMINOGEN-ACTIVATOR ACTIVITY

被引：10

作者：

DESIMONE, DP

REDDI, AH

机构：

[1] MT SINAI MED CTR,DEPT ORTHOPAED,NEW YORK,NY 10029

[2] NIDR,BONE CELL BIOL SECT,BETHESDA,MD 20892

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 1992年 / 10卷 / 03期

关键词：

PLASMINOGEN; VASCULARIZATION; CALCIFICATION; CARTILAGE; ENDOTHELIUM; ENDOCHONDRAL BONE FORMATION;

D O I：

10.1002/jor.1100100303

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Changes in plasminogen activator activity were studied during the sequential developmental stages of matrix-induced cartilage, bone, and bone marrow development. The morphological transitions were correlated with biochemical parameters. Morphologic evidence of vascularization of calcified hypertrophic cartilage was accompanied by a concomitant rise in plasminogen activator activity. Thereafter, a steady decline during mineralization and deposition of new bone was observed. Maximal plasminogen activator activity occurs at approximately the same time as peak activity of alkaline and acid phosphatase. These results imply a role for plasminogen activator during angiogenesis, vascular invasion, and attendant bone differentiation.

引用

页码：320 / 324

页数：5

共 23 条

[1] TUMORIGENICITY OF HERPESVIRUS-TRANSFORMED CELLS CORRELATED WITH PRODUCTION OF PLASMINOGEN-ACTIVATOR [J].