A PHYSIOLOGICAL MODEL OF GLUCOSE INSULIN INTERACTION IN TYPE-1 DIABETES-MELLITUS

被引：242

作者：

LEHMANN, ED

DEUTSCH, T

机构：

[1] CITY UNIV LONDON,CTR MEASUREMENT & INFORMAT MED,DEPT SYST SCI,LONDON EC1V 0HB,ENGLAND

[2] SEMMELWEIS UNIV MED,CTR COMP,H-1085 BUDAPEST 8,HUNGARY

来源：

JOURNAL OF BIOMEDICAL ENGINEERING | 1992年 / 14卷 / 03期

关键词：

COMPUTER SIMULATION; PHYSIOLOGICAL MODEL; TYPE-1; DIABETES-MELLITUS; INSULIN DOSAGE ADJUSTMENT;

D O I：

10.1016/0141-5425(92)90058-S

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A clinical model of glucose-insulin interaction in insulin-dependent diabetes mellitus has been developed for patient and medical staff education. The model attempts to reflect the underlying (patho)physiology of insulin action and carbohydrate absorption in quantitative terms such as insulin sensitivity, volume of glucose and insulin distribution and maximal rate of gastric emptying. The model's predictions also allow a 24 h simulation of patient blood glucose profiles to be generated. A description of the model is provided and its operation illustrated by clinical case studies of insulin-treated diabetic patients. The possible use of the model as a tool for automated insulin dosage adjustment is explored.

引用

页码：235 / 242

页数：8

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