STATISTICAL AND ETHICAL ISSUES IN THE DESIGN AND CONDUCT OF PHASE-I AND PHASE-II CLINICAL-TRIALS OF NEW ANTICANCER AGENTS

被引：142

作者：

RATAIN, MJ ^{[1
]}

MICK, R ^{[1
]}

SCHILSKY, RL ^{[1
]}

SIEGLER, M ^{[1
]}

机构：

[1] UNIV CHICAGO,PRITZKER SCH MED,CTR CLIN MED ETH,CHICAGO,IL 60637

来源：

JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1993年 / 85卷 / 20期

关键词：

D O I：

10.1093/jnci/85.20.1637

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：1637 / 1643

页数：7

共 72 条

[1]

AISNER J, 1987, CANCER TREAT REP, V71, P1131

[2] APPLICATION OF THE TRIANGULAR TEST TO PHASE-II CANCER CLINICAL-TRIALS [J].

BELLISSANT, E ;

BENICHOU, J ;

CHASTANG, C .

STATISTICS IN MEDICINE, 1990, 9 (08) :907-917

[3] EPIRUBICIN IN EXTENSIVE SMALL-CELL LUNG-CANCER - A PHASE-II STUDY IN PREVIOUSLY UNTREATED PATIENTS - A NATIONAL CANCER INSTITUTE OF CANADA CLINICAL-TRIALS GROUP-STUDY [J].

BLACKSTEIN, M ;

EISENHAUER, EA ;

WIERZBICKI, R ;

YOSHIDA, S .

JOURNAL OF CLINICAL ONCOLOGY, 1990, 8 (03) :385-389

[4]

BOLOGNESE JA, 1983, CONTROL CLIN TRIALS, V4, P187

[5]

Breslow N., 1990, STAT SCI, V5, P269

[6] A PHASE-I TRIAL OF SPIROHYDANTOIN MUSTARD (NSC-172112) IN PATIENTS WITH ADVANCED CANCER [J].

BROWN, TD ;

ETTINGER, DS ;

DONEHOWER, RC .

JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (08) :1270-1276

[7]

CLAYTON DG, 1982, BRIT J CLIN PHARMACO, V13, P469

[8]

COLLINS JM, 1986, CANCER TREAT REP, V70, P73

[9] PHARMACOLOGICALLY GUIDED PHASE-I CLINICAL-TRIALS BASED UPON PRECLINICAL DRUG DEVELOPMENT [J].

COLLINS, JM ;

GRIESHABER, CK ;

CHABNER, BA .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (16) :1321-1326

[10]

CULLEN M, 1989, LUNG CANCER, V5, P214

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