SUPPRESSION OF ODORANT RESPONSES BY ODORANTS IN OLFACTORY RECEPTOR-CELLS

被引：91

作者：

KURAHASHI, T ^{[1
]}

LOWE, G ^{[1
]}

GOLD, GH ^{[1
]}

机构：

[1] MONELL CHEM SENSES CTR,PHILADELPHIA,PA 19104

来源：

SCIENCE | 1994年 / 265卷 / 5168期

关键词：

D O I：

10.1126/science.8016645

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Odorants activate an inward current in vertebrate olfactory receptor cells. Here it is shown, in receptor cells from the newt, that odorants can also suppress this current, by a mechanism that is distinct from inhibition and adaptation. Suppression provides a simple explanation for two seemingly unrelated phenomena: the anomalously long latency of olfactory transduction and the existence of an ''off response'' at the end of a prolonged stimulus. Suppression may influence the perception of odorants by masking odorant responses and by sharpening the odorant specificities of single cells.

引用

页码：118 / 120

页数：3

共 46 条

[1] TRANSDUCTION PROTEINS OF OLFACTORY RECEPTOR-CELLS - IDENTIFICATION OF GUANINE-NUCLEOTIDE BINDING-PROTEINS AND PROTEIN-KINASE-C [J].