A FAMILIAL ALZHEIMERS-DISEASE LOCUS ON CHROMOSOME-1

被引：628

作者：

LEVYLAHAD, E

WIJSMAN, EM

NEMENS, E

ANDERSON, L

GODDARD, KAB

WEBER, JL

BIRD, TD

SCHELLENBERG, GD

机构：

[1] VET ADM MED CTR, CTR GERIATR RES EDUC & CLIN, SEATTLE, WA 98108 USA

[2] UNIV WASHINGTON, DEPT MED, DIV MED GENET, SEATTLE, WA 98195 USA

[3] UNIV WASHINGTON, DEPT BIOSTAT, SEATTLE, WA 98195 USA

[4] MARSHFIELD MED RES FDN, MARSHFIELD, WI 54449 USA

[5] VET AFFAIRS MED CTR, DIV NEUROL, SEATTLE, WA 98108 USA

来源：

SCIENCE | 1995年 / 269卷 / 5226期

关键词：

D O I：

10.1126/science.7638621

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Volga German kindreds are a group of seven related families with autosomal dominant early-onset Alzheimer's disease (AD). Linkage to known AD-related loci on chromosomes 21 and 14 has been excluded. Significant evidence for linkage to AD in these families was obtained with D1S479 and there was also positive evidence for linkage with other markers in the region. A 112-base pair allele of D1S479 co-segregated with the disease in five of seven families, which is consistent with a common genetic founder. This study demonstrates the presence of an AD locus on chromosome 1q31-42.

引用

页码：970 / 973

页数：4

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