HISTAMINE SYNTHESIS INHIBITION REDUCES LIGHT-INDUCED PHASE-SHIFTS OF CIRCADIAN-RHYTHMS

被引：16

作者：

EATON, SJ ^{[1
]}

COTE, NK ^{[1
]}

HARRINGTON, ME ^{[1
]}

机构：

[1] SMITH COLL,DEPT PSYCHOL,NORTHAMPTON,MA 01063

来源：

BRAIN RESEARCH | 1995年 / 695卷 / 02期

关键词：

CIRCADIAN RHYTHM; ALPHA-FLUOROMETHYLHISTIDINE; FMH; HAMSTER; HISTAMINE; LIGHT; SUPRACHIASMATIC NUCLEUS;

D O I：

10.1016/0006-8993(95)00635-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Circadian rhythms are generated by the hypothalamic suprachiasmatic nuclei, a site of dense histaminergic innervation. Histamine can phase shift circadian rhythms in a manner similar to light. In this experiment, we administered alpha-fluoromethylhistidine (FMH), an inhibitor of histamine synthesis, prior to a light pulse in hamsters housed under constant darkness. Photic phase shifts in wheel-running rhythms were significantly attenuated by FMH pretreatment. These results suggest that histamine may modulate photic input to the circadian clock.

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收藏

页码：227 / 230

页数：4

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