EFFECTS OF 3',5'-CYCLIC ADENOSINE MONOPHOSPHATE AND ITS DIBUTYRYL DERIVATIVE ON MOTILITY OF ISOLATED RAT ILEUM

被引：17

作者：

KAWASAKI, A

KASHIMOTO, T

YOSHIDA, H

机构：

[1] Department of Pharmacology, Faculty of Medicine, Osaka University, Osaka, Kita-Ku

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1969年 / 19卷 / 04期

关键词：

D O I：

10.1254/jjp.19.494

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Dibutyryl-cyclic AMP and caffeine caused relaxation of the rat ileum in Tyrode solution, but ATP and ADP caused contraction, and cyclic AMP and AMP caused transient relaxation followed by contraction. 2. The relaxing effect of dibutyryl-cyclic AMP on the ileum in high K+ medium was potentiated by caffeine. In high K#x002B; medium, cyclic AMP like AMP, had no signi ficant relaxing effect on the ileum. But, by the presence of caffeine in high K#x002B; medium, cyclic AMP caused marked relaxation while AMP had little effect. 3. The relaxing effect of dibutyryl-cyclic AMP on isolated rat ileum was not blocked by DCI, either in normal Tyrode solution or in high K#x002B; medium. 4. The possibility that adenyl cyclase is a β-receptor of catecholamine and that cyclic AMP, formed by the enzyme, may act as an intracellular regulator in smooth muscle. © 1969, The Japanese Pharmacological Society. All rights reserved.

引用

页码：494 / +

页数：1

共 16 条

[1] SIGNIFICANCE OF ADENOSINE CYCLIC 3',5'-MONOPHOSPHATE FOR CONTRACTION OF SMOOTH MUSCLE [J].