STUDY OF CHEMICAL CARCINOGENESIS .20. TUMOR INITIATING ACTIVITY OF 5,11-DIMETHYLCHRYSENE AND THE STRUCTURAL REQUIREMENTS FAVORING CARCINOGENICITY OF METHYLATED POLYNUCLEAR AROMATIC-HYDROCARBONS

被引：48

作者：

HECHT, SS

AMIN, S

RIVENSON, A

HOFFMANN, D

机构：

[1] Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla

来源：

CANCER LETTERS | 1979年 / 8卷 / 01期

关键词：

D O I：

10.1016/0304-3835(79)90024-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tumor initiating activities of 5,11-dimethylchrysene and 5-methylchrysene on mouse skin were compared. After initiating doses of 30 μg or 10 μg, with promotion by 3 times weekly applications of tetradecanoylphorbol acetate, both compounds were highly tumorigenic, inducing tumors in 70-85% of the treated animals. Since 5,12-dimethylchrysene had previously been shown to be only a weak tumor initiator, these results support the generalization that the structural requirements favoring carcinogenicity among the methylated chrysenes and other polynuclear aromatic hydrocarbons (PAH) are a bay region methyl group and a free peri position, both adjacent to an unsubstituted angular ring. © 1979.

引用

页码：65 / 70

页数：6

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