EFFECTS OF DOPAMINE, BROMOCRIPTINE, LERGOTRILE AND METOCLOPRAMIDE ON PROLACTIN-RELEASE FROM CONTINUOUSLY PERFUSED COLUMNS OF ISOLATED RAT PITUITARY CELLS

被引：125

作者：

YEO, T

THORNER, MO

JONES, A

LOWRY, PJ

BESSER, GM

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT ENDOCRINOL,LONDON EC1A 7BE,ENGLAND

[2] ST BARTHOLOMEWS HOSP,DEPT CHEM PATHOL,LONDON EC1A 7BE,ENGLAND

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 02期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb01357.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The control of secretion of prolactin was studied using continuous perfusion of a column of isolated rat pituitary cells supported by Bio‐Gel polyacrylamide beads. Prolactin secretion was inhibited repeatedly by dopamine and rapidly recovered in its absence. Maximum inhibition was achieved at 5 ± 107 M dopamine. Bromocriptine and lergotrile directly inhibited prolactin release from the pituitary cells. Bromocriptine had a longterm action in inhibiting secretion. The dopamine receptor blocking agent, metoclopramide, overcame the inhibitory effect of dopamine but had no effect on prolactin secretion in its absence. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：123 / 130

页数：8

共 19 条

[1]

BESSER GM, 1977, PROGR REPRODUCTION B, V2, P261

[2] EFFECT OF METOCLOPRAMIDE ON SERUM PROLACTIN LEVELS IN HUMANS [J].