CHANGES IN ANTI-PLASMIN AND PLASMIN ACTIVITIES DURING EXTREME HEMODILUTION AND OPEN-HEART SURGERY IN DOGS

被引：6

作者：

AASEN, AO ^{[1
]}

GALLIMORE, MJ ^{[1
]}

LILLEAASEN, P ^{[1
]}

LYNGAAS, K ^{[1
]}

LARSBRAATEN, M ^{[1
]}

AMUNDSEN, E ^{[1
]}

机构：

[1] RIKSHOSP,INST SURG RES,DEPT SURG A,OSLO,NORWAY

来源：

EUROPEAN SURGICAL RESEARCH | 1979年 / 11卷 / 03期

关键词：

'Fast-reacting' antiplasmin Plasmin activity; Cardiac surgery; Chromogenic substrate assays; Extreme hemodilution; Oj-Antiplasmin; Total' antiplasmin; α[!sub]2[!/sub]-Macroglobulin;

D O I：

10.1159/000128061

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The effects of extreme hemodilution and open heart surgery on antiplasmin and plasmin activities were investigated in dogs. Assays for plasmin and antiplasmin activities were performed with a chromogenic peptide substrate for plasmin. After hemo-dilution and during cardiopulmonary bypass (CPB), plasmin activity on the substrate was observed and levels of both 'fast-reacting' and 'total' antiplasmins fell. The plasmin activity was shown to be due to the formation of α2-macroglobulin-plasmin complex which exhibited amidolytic activity on the chromogenic substrate. The falls in antiplasmin activity together with the appearance of the a,-macroglobulin-plasmin complex revealed that activation of the fibrinolytic system had occurred. After the operation and following rein-fusion of autologous blood, decreased plasmin and increased antiplasmin activities were observed. On the first and sixth days following the operation plasmin activities were still slightly higher than pre-operation values, whilst antiplasmin activities were normal. © 1979 S. Karger AG, Basel.

引用

页码：145 / 153

页数：9

共 33 条

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