EPIDERMAL GROWTH-FACTOR RECEPTOR AND BLADDER-CANCER - A REVIEW

被引：70

作者：

NEAL, DE

MELLON, K

机构：

[1] Department of Urology, Freeman Hospital, University of Newcastle upon Tyne

来源：

UROLOGIA INTERNATIONALIS | 1992年 / 48卷 / 04期

关键词：

BLADDER; CANCER; EPIDERMAL GROWTH FACTOR; RECEPTOR; PROGNOSIS; C-ERB-2;

D O I：

10.1159/000282357

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, expectations have been raised that molecular biological studies of human tumours may be of value in helping to predict future clinical behaviour, in terms of therapeutic response and long-term survival. The epidermal growth factor receptor (EGFr) is a cell surface receptor for EGF and transforming growth factor-alpha which is overexpressed by a number of human tumours. This article principally reviews previous investigations of the role of the epidermal growth factor receptor in bladder cancer and examines methods of detection, the correlation between EGFr status and known prognostic indicators and the value of assessing EGFr status in predicting clinical outcome in patients with bladder cancer. Recent studies of the c-erbB-2 proto-oncogene in bladder cancer and of cell cycling using Ki-67 are included.

引用

页码：365 / 371

页数：7

共 38 条

[1]

Sporn M.B., Roberts A.B., Autocrine growth factors and cancer, Nature, 313, pp. 745-747, (1985)

[2]

Heldin C.-H., Westermark B., Growth factors: Mechanism of action and relation to oncogenes, Cell, 37, pp. 9-20, (1984)

[3]

Waierfield M.D., Scrace G.T., Whittle N., Stroo-Bant P., Johnsson A., Wasteson A., Westermark B., Heldin C.H., Huang J.S., Deuel T.F., Platelet derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus, Nature, 304, pp. 35-39, (1983)

[4]

Downward J., Yarden Y., Mayes E., Scrace G., Totty N., Stockwell P., Ullrich A., Schlessinger J., Waterfield M.D., Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences, Nature, 307, pp. 521-527, (1984)

[5]

Kelly K., Cochran B.H., Stiles C.D., Leder P., Cell specific regulation of the c-mir gene by lymphocyte mitogens and platelet derived growth factor, Cell, 35, pp. 603-610, (1983)

[6]

Stiles C.D., Caponc G.T., Schcr C.D., Antoniades H.N., Van Wyk J.J., Pledger W.J., Dual control of cell growth by somatomedins and platelet-derived growth factor, Proc Natl Acad Sci, 76, pp. 1279-1283, (1979)

[7]

Cohen S., The epidermal growth factor, Cancer, 51, pp. 1787-1791, (1983)

[8]

Kasselberg A.G., Orth D.N., Gray M.E., Stahlman M.T., Immunocytochemical localisation of human epidermal growth factorzurogastrone in several human tissues, J Histochem Cytochem, 33, pp. 315-322, (1985)

[9]

Osborne C.K., Hamilton B., Nover M., Receptor binding and processing of epidermal growth factor by human breast cancer cells, J Clin Endocrinol Metab, 55, pp. 86-93, (1982)

[10]

Fitzpatrick S.L., Brightwell J., Wittliff J.L., Barrows G.H., Schullz G.S., Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen and progestin receptor levels, Cancer Res, 44, pp. 3448-3453, (1984)

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