1992 VOLVO AWARD IN EXPERIMENTAL STUDIES - FIBRINOLYTIC-ACTIVITY AS A PREDICTOR OF THE OUTCOME OF PROLAPSED INTERVERTEBRAL LUMBAR-DISK SURGERY WITH REFERENCE TO BACKGROUND VARIABLES - RESULTS OF A PROSPECTIVE COHORT STUDY

被引：20

作者：

HAALAND, AK

GRAVER, V

LJUNGGREN, AE

LOEB, M

LIE, H

MAGNAES, B

GODAL, HC

机构：

[1] Ulleval University Hospital, Oslo

来源：

SPINE | 1992年 / 17卷 / 09期

关键词：

PROLAPSED INTERVERTEBRAL DISK; FIBRINOLYSIS; SURGICAL OUTCOME; BACKGROUND VARIABLES;

D O I：

10.1097/00007632-199209000-00003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a prospective study 122 patients with a slipped lumbar disc and no previous surgery were preoperatively examined for fibrinolytic activity. Surgical results for these patients were evaluated 12 months postoperatively by clinical overall assessment. In a multiple linear regression analysis fibrinolytic variables, euglobulin clot lysis time and plasminogen activator inhibitor 1, were shown to have predictive value regarding outcome of surgery; that is, normal fibrinolytic activity favors a satisfactory outcome and vice versa. Background variables and lipid profile were also recorded preoperatively. Body mass index, GAMMA-glutamyl transpeptidase, triglycerides and smoking were of statistical significance in relation to euglobulin clot lysis time and plasminogen activator inhibitor 1. Postoperative fibrinolytic re-examination of 20 patients seem to confirm that patients at risk of surgical failure have a prolonged depression of fibrinolytic activity.

引用

页码：1022 / 1027

页数：6

共 21 条

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