INVIVO DEGRADATION OF SILICONES

被引：73

作者：

GARRIDO, L ^{[1
]}

PFLEIDERER, B ^{[1
]}

PAPISOV, M ^{[1
]}

ACKERMAN, JL ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

MAGNETIC RESONANCE IN MEDICINE | 1993年 / 29卷 / 06期

关键词：

SILICONES; DEGRADATION; NMR;

D O I：

10.1002/mrm.1910290620

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Si-29 nuclear magnetic resonance (NMR) spectroscopy is applied to study the degradation of polysiloxanes (silicones) in vivo. Our results with animal models show that silicone migrates from the implant to the liver (Si-29 resonance at -20 ppm) and new silicon containing compounds form after the silicones are introduced into the rats. The new Si-29 resonances in the chemical shift range of -40 to -85 ppm are related to hydrolyzed silicone, those at -90 to -115 ppm are indicative of the presence of silica (SiO2), and the peaks observed at -120 to -150 are related to high coordinated silicon complexes. These resonances are not present in the Si-29 spectra of the silicones before implantation. Our findings demonstrate that silicones are not metabolically inert.

引用

页码：839 / 843

页数：5

共 27 条

[1] SURFACE ULTRASTRUCTURE OF SILICONE-RUBBER AORTIC-VALVE POPPETS AFTER LONG-TERM IMPLANTATION - SCANNING ELECTRON-MICROSCOPE STUDY OF 4 POPPETS [J].