SYNTHESIS AND EVALUATION OF SOME STABLE MULTISUBSTRATE ADDUCTS AS SPECIFIC INHIBITORS OF SPERMIDINE SYNTHASE

被引:61
作者
TANG, KC
MARIUZZA, R
COWARD, JK
机构
[1] RENSSELAER POLYTECH INST,DEPT CHEM,TROY,NY 12181
[2] YALE UNIV,SCH MED,DEPT PHARMACOL,NEW HAVEN,CT 06510
关键词
D O I
10.1021/jm00143a003
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1277 / 1284
页数:8
相关论文
共 19 条
[1]  
ANDERSON GL, 1981, J MED CHEM, V24, P1269
[2]   SYNTHESIS OF S-5'-DEOXYADENOSINE-5'-HOMOCYSTEINE, A PRODUCT FROM ENZYMIC METHYLATIONS INVOLVING ACTIVE METHIONINE [J].
BADDILEY, J ;
JAMIESON, GA .
JOURNAL OF THE CHEMICAL SOCIETY, 1955, :1085-1089
[3]   MECHANISM OF ALKALINE-HYDROLYSIS OF S-ADENOSYL-L-METHIONINE AND RELATED SULFONIUM NUCLEOSIDES [J].
BORCHARDT, RT .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (02) :458-463
[4]   INVESTIGATION OF METHODS FOR PREPARING PURE SECONDARY ALKYL HALIDES [J].
CASON, J ;
CORREIA, JS .
JOURNAL OF ORGANIC CHEMISTRY, 1961, 26 (10) :3645-&
[5]  
CLARKE CT, 1978, J CHEM SOC P1, V1, P1088
[6]   CLEAVAGE OF N-CARBOBENZYLOXY GROUP IN NEUTRAL AND BASIC MEDIA - NEIGHBORING-GROUP PARTICIPATION OF CARBAMATE MOIETY [J].
COWARD, JK ;
LOK, R .
JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (14) :2546-2548
[7]   POLYAMINE BIOSYNTHESIS IN RAT PROSTATE - SUBSTRATE AND INHIBITOR PROPERTIES OF 7-DEAZA ANALOGS OF DECARBOXYLATED S-ADENOSYLMETHIONINE AND 5'-METHYLTHIOADENOSINE [J].
COWARD, JK ;
MOTOLA, NC ;
MOYER, JD .
JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (04) :500-505
[8]   KINETIC STUDIES ON CATECHOL O-METHYLTRANSFERASE - PRODUCT INHIBITION AND NATURE OF CATECHOL BINDING-SITE [J].
COWARD, JK ;
SLISZ, EP ;
WU, FYH .
BIOCHEMISTRY, 1973, 12 (12) :2291-2297
[9]   ANALOGS OF S-ADENOSYLHOMOCYSTEINE AS POTENTIAL INHIBITORS OF BIOLOGICAL TRANSMETHYLATION - INHIBITION OF SEVERAL METHYLASES BY S-TUBERCIDINYLHOMOCYSTEINE [J].
COWARD, JK ;
BUSSOLOTTI, DL ;
CHANG, CD .
JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (12) :1286-1289
[10]   STUDIES OF INHIBITION OF RAT SPERMIDINE SYNTHASE AND SPERMINE SYNTHASE [J].
HIBASAMI, H ;
BORCHARDT, RT ;
CHEN, SY ;
COWARD, JK ;
PEGG, AE .
BIOCHEMICAL JOURNAL, 1980, 187 (02) :419-428