ROLE OF CALCIUM IN THE BOMBESIN-INDUCED INTESTINAL CCK RELEASE IN RATS

被引:2
作者
AUCOUTURIER, S
CUBER, JC
BERNARD, C
CHAYVIALLE, JA
机构
[1] HOP EDOUARD HERRIOT,INSERM,UNITE 45,PAVILLON H,F-69437 LYON 03,FRANCE
[2] INRA,ECOL & PHYSIOL SYST DIGEST,F-78350 JOUY EN JOSAS,FRANCE
关键词
ISOLATED DUODENOJEJUNUM; RAT; CCK; BOMBESIN; CALCIUM;
D O I
10.1016/0196-9781(93)90189-N
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the isolated vascularly perfused rat duodenojejunum, vascular infusion of bombesin (100 nM) provoked an early, transient (6 min) release of CCK (500% of basal), followed by a sustained response (400% of basal). The calcium chelator EGTA (2 mM) reduced the early peak and abolished the second phase of CCK release. A similar variation was evoked by verapamil (10 muM), whereas diltiazem (100 muM), nifedipine (50 muM), and omega-conotoxin (100 nM) had no significant effect. It is concluded that bombesin-induced CCK release from rat intestine is dependent on the availability of extracellular calcium and on the activation of calcium channels sensitive to blockers of the phenylalkylamine family.
引用
收藏
页码:1295 / 1297
页数:3
相关论文
共 12 条
[1]   RELEASE AND CHARACTERIZATION OF CHOLECYSTOKININ FROM ISOLATED CANINE JEJUNAL CELLS [J].
BARBER, DL ;
WALSH, JH ;
SOLL, AH .
GASTROENTEROLOGY, 1986, 91 (03) :627-636
[2]   ROLE OF CALCIUM IN MONITOR PEPTIDE-STIMULATED CHOLECYSTOKININ RELEASE FROM PERIFUSED INTESTINAL-CELLS [J].
BOURAS, EP ;
MISUKONIS, MA ;
LIDDLE, RA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (05) :G791-G796
[3]   BLOCKADE OF BOMBESIN RECEPTORS WITH [LEU14-PSI(CH2NH)-LEU13]BOMBESIN FAILS TO SUPPRESS NUTRIENT-INDUCED CCK RELEASE FROM RAT DUODENOJEJUNUM [J].
CUBER, JC ;
BERNARD, G ;
COY, DH ;
BERNARD, C ;
CHAYVIALLE, JA .
PEPTIDES, 1990, 11 (02) :255-258
[4]   BOMBESIN AND NUTRIENTS STIMULATE RELEASE OF CCK THROUGH DISTINCT PATHWAYS IN THE RAT [J].
CUBER, JC ;
VILAS, F ;
CHARLES, N ;
BERNARD, C ;
CHAYVIALLE, JA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (06) :G989-G996
[5]   ROLE OF CYCLIC-NUCLEOTIDES AND CALCIUM IN THE NUTRIENT-INDUCED RELEASE OF CHOLECYSTOKININ-LIKE IMMUNOREACTIVITY IN RATS [J].
CUBER, JC ;
AUCOUTURIER, S ;
BERNARD, C ;
CHAYVIALLE, JA .
JOURNAL OF PHYSIOLOGY-LONDON, 1992, 449 :37-48
[6]   INFLUENCE OF VERAPAMIL ON GASTRIC-ACID SECRETION AND GASTRIN-RELEASE IN DOGS [J].
GRIMM, G ;
SALEM, G ;
PRAGERPETZ, J ;
PILS, P ;
GLOECKLER, M ;
SADOWSKY, J ;
POINTNER, H .
DIGESTION, 1985, 32 (04) :282-287
[7]   ROLE OF CA-2+ IN BOMBESIN-STIMULATED RELEASE OF GASTRIN AND SOMATOSTATIN FROM ISOLATED PERFUSED RAT STOMACH [J].
GUO, YS ;
THOMPSON, JC ;
SINGH, P .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (05) :G627-G632
[8]  
IWAI K, 1987, J BIOL CHEM, V262, P8956
[9]  
JANSEN JBMJ, 1984, SURGERY, V96, P55
[10]   CHOLECYSTOKININ CELLS PURIFIED BY FLUORESCENCE-ACTIVATED CELL SORTING RESPOND TO MONITOR PEPTIDE WITH AN INCREASE IN INTRACELLULAR CALCIUM [J].
LIDDLE, RA ;
MISUKONIS, MA ;
PACY, L ;
BALBER, AE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (11) :5147-5151