LARGE RATE ENHANCEMENT FOR THE HYDROLYSIS OF A 4-MEMBERED RING PHOSPHONAMIDATE

被引：6

作者：

LAWS, AP ^{[1
]}

STONE, JR ^{[1
]}

PAGE, MI ^{[1
]}

机构：

[1] UNIV HUDDERSFIELD, DEPT CHEM & BIOL SCI, HUDDERSFIELD HD1 3DH, W YORKSHIRE, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 10期

关键词：

D O I：

10.1039/c39940001223

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Unlike beta-lactams a four-membered cyclic 1,2-azaphosphetidine shows enhanced hydrolytic reactivity compared with an acyclic analogue; the cyclic phosphonamidate 3 undergoes hydroxide-ion catalysed hydrolysis in water with endocyclic P-N fission; a corresponding acyclic derivative hydrolyses with P-O fission in basic solution, the rate difference between the cyclic and acyclic structures for P-N fission is greater than 5 x 10(8).

引用

页码：1223 / 1224

页数：2

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