SYNTHETIC PEPTIDE RECEPTOR MIMICS - HIGHLY STEREOSELECTIVE RECOGNITION IN NONCOVALENT MOLECULARLY IMPRINTED POLYMERS

被引：123

作者：

RAMSTROM, O ^{[1
]}

NICHOLLS, IA ^{[1
]}

MOSBACH, K ^{[1
]}

机构：

[1] LUND UNIV,CTR CHEM,DEPT PURE & APPL BIOCHEM,S-22100 LUND,SWEDEN

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 04期

关键词：

D O I：

10.1016/0957-4166(94)80027-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Ligand-receptor recognition has been studied in a molecularly imprinted polymer (MIP) prepared against N-Ac-L-Phe-L-Trp-OMe. The non-ionic non-covalent interaction based recognition was evaluated using the polymers as chiral HPLC stationary phases. Marked regio-, enantio- and diastereo- ligand selectivity were demonstrated with enantiomer separation Factors of up to 17.8. The interaction of a series of related structures with the MIP receptor site has provided insight concerning its nature and the recognition mechanisms.

引用

页码：649 / 656

页数：8

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