POSITIVE-ION FAST-ATOM-BOMBARDMENT TANDEM MASS-SPECTROMETRY OF PEPTIDE NUCLEIC-ACIDS

被引：10

作者：

TAKAO, T

FUKUDA, H

COULL, J

SHIMONISHI, Y

机构：

[1] NIHON PERSEPT LTD,SHINAGAWA KU,TOKYO 140,JAPAN

[2] PERSEPT BIOSYST INC,BEDFORD,MA 01730

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1994年 / 8卷 / 12期

关键词：

D O I：

10.1002/rcm.1290081203

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The base sequence of synthetic peptide nucleic acids (PNAs), novel antisense agents, was analyzed by positive-ion fast-atom bombardment tandem mass spectrometry (FAB-MS/MS). Upon high-energy collisional activation decomposition, PNA oligomers provided apparent MS/MS product ions resulting from specific cleavage along the PNA backbone.

引用

页码：925 / 928

页数：4

共 9 条

[1]

CHRISTENSEN L, 1993, 13TH AM PEPT S EDM

[2]

ENGHOLM M, 1992, J AM CHEM SOC, V114, P1895

[3]

ENGHOLM M, 1992, J AM CHEM SOC, V114, P9677

[4]

FRUM H, 1993, NUCLEIC ACIDS RES, V21, P5332