SYNTHESIS OF BORON CARRIERS FOR NEUTRON-CAPTURE THERAPY AND STUDIES OF ACTIVATED IMINES

Boron Neutron Capture Therapy (BNCT) has been promising therapeutic principles of cancers. Synthesis of several new boron carriers having more appropriate biological activities than clinically used boron compounds has been accomplished. New methods for the synthesis of boron carriers are described. In addition, studies of activated imines like an acyliminium ion or an imine attached with electron withdrawing group on nitrogen, are presented. New synthetic methods and reagents for the reaction of activated imines are also described.