LIPID-COMPOSITION OF RAT-BRAIN AGGREGATING CELL-CULTURES DURING DEVELOPMENT

被引：7

作者：

BOURRE, JM

HONEGGER, P

DAUDU, O

MATTHIEU, JM

机构：

[1] UNIV LAUSANNE,INST PHYSIOL,CH-1011 LAUSANNE,SWITZERLAND

[2] HOP SALPETRIERE,CNRS,EQUIPE RECH 421,INSERM,NEUROCHIM LAB,U134,F-75634 PARIS 13,FRANCE

[3] UNIV LAUSANNE,SERV PEDIAT,CH-1011 LAUSANNE,SWITZERLAND

来源：

NEUROSCIENCE LETTERS | 1979年 / 11卷 / 03期

关键词：

D O I：

10.1016/0304-3940(79)90007-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The lipid and fatty acid composition of rat brain was studied during its development both in vivo and in an aggregating cell culture system. Although the amount of lipid present in the cultures was very low, the increase in glycolipid content corresponded closely to the period of intense myelin formation. Very long chain fatty acids (hydroxylated and unsubstituted) were present in 41-day cultures. In comparison to the in vivo situation, myelination was delayed in vitro and, after 40 days in culture, cholesterol esters were 5-fold higher than in vivo, indicating that demyelination was occuring. © 1979.

引用

页码：275 / 278

页数：4

共 9 条

[1] MYELIN CONSISTS OF A CONTINUUM OF PARTICLES OF DIFFERENT DENSITY WITH VARYING LIPID-COMPOSITION - MAJOR DIFFERENCES ARE FOUND BETWEEN NORMAL MICE AND QUAKING MUTANTS [J].