VITAMIN-E IN KITTEN OXYGEN-INDUCED RETINOPATHY .2. BLOCKAGE OF VITREAL NEOVASCULARIZATION

被引：40

作者：

PHELPS, DL ^{[1
]}

ROSENBAUM, AL ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,JULES STEIN EYE INST,DEPT OPHTHALMOL,LOS ANGELES,CA 90024

来源：

ARCHIVES OF OPHTHALMOLOGY | 1979年 / 97卷 / 08期

关键词：

D O I：

10.1001/archopht.1979.01020020184021

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The effect of vitamin E (tocopherol) on oxygen-induced retinopathy was studied in the kitten after a quantitative scoring system was developed for their India ink injected retinal flat preparations. In 75 previously described kittens exposed to two or three days of oxygen from day 3, treatment from day 1 with vitamin E or placebo disclosed that kittens treated with vitamin E had less retinopathy. Theories of the mechanism of action of vitamin E would predict that, if given only after the oxygen exposure, vitamin E should be ineffective. This was tested in 37 kittens with placebo or drug begun only after withdrawal from oxygen. Unexpectedly, significantly less intravitreal neovascularization was found in kittens treated with vitamin E after oxygen exposure. © 1979, American Medical Association. All rights reserved.

引用

页码：1522 / 1526

页数：5

共 14 条

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