FIBROBLAST GROWTH-FACTOR INHIBITS 5-ALPHA-REDUCTASE ACTIVITY IN CULTURED IMMATURE LEYDIG-CELLS

被引：29

作者：

MURONO, EP

WASHBURN, AL

机构：

[1] UNIV S CAROLINA, SCH MED, DEPT PHYSIOL, COLUMBIA, SC 29208 USA

[2] WILLIAM JENNINGS BRYAN DORN VET ADM MED CTR, RES SERV, COLUMBIA, SC USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1990年 / 68卷 / 01期

关键词：

5α-Reductase; Basic fibroblast growth factor; Leydig cell;

D O I：

10.1016/0303-7207(90)90176-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The present studies examined the effects of basic fibroblast growth factor (bFGF) on 5α-reductase activity of cultured Leydig cells from immature rats. Basic FGF inhibited both hCG- and 8-bromo-cyclic AMP-stimulated 5α-reductase activity in a dose-dependent manner; however, it had little or no effect on basal enzyme activity. Inhibition was achieved with as little as 0.1 ng/ml bFGF, and maximal inhibition was observed with 10 ng/ml bFGF. These studies suggest that locally produced bFGF may play a role in modulating the age-dependent decline in 5α-reductase activity in Leydig cells. © 1990.

引用

页码：R19 / R23

页数：5

共 31 条

[1] BASIC FIBROBLAST GROWTH-FACTOR AS A REGULATOR OF OVARIAN GRANULOSA-CELL DIFFERENTIATION - A NOVEL NON-MITOGENIC ROLE [J].