POSTHEPARIN LIPOLYTIC-ACTIVITY AND PLASMA-LIPOPROTEIN RESPONSE TO OMEGA-3 POLYUNSATURATED FATTY-ACIDS IN PATIENTS WITH PRIMARY HYPERTRIGLYCERIDEMIA

被引:56
作者
NOZAKI, S
GARG, A
VEGA, GL
GRUNDY, SM
机构
[1] UNIV TEXAS,SW MED CTR,CTR HUMAN NUTR,5323 HARRY HINES BLVD,DALLAS,TX 75235
[2] UNIV TEXAS,SW MED CTR,DEPT CLIN NUTR,DALLAS,TX 75235
[3] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,DALLAS,TX 75235
[4] UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,DALLAS,TX 75235
[5] VET ADM MED CTR,DALLAS,TX 75216
关键词
OMEGA-3 POLYUNSATURATED FATTY ACIDS; LIPOPROTEINS; LIPOPROTEIN LIPASE; HYPERLIPOPROTEINEMIA TYPE-IV; HEPATIC LIPASE;
D O I
10.1093/ajcn/53.3.638
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The hypotriglyceridemic action of omega-3 (n-3) fatty acids is attributed primarily to reduction in hepatic triglyceride synthesis and reduced secretion of very-low-density lipoproteins (VLDLs). However, increased catabolism of triglyceride-rich lipoproteins was reported and could be due to increased availability of peripheral lipoprotein lipase (LPL) or hepatic lipase (HL). In this study plasma lipoproteins and postheparin activities of LPL and HL were determined in 12 patients with primary hypertriglyceridemia before and during isocaloric substitution of omega-3 fatty acids (10 g/d) for 4 wk. Omega-3 polyunsaturates resulted in 53% and 61% reductions in plasma triglyceride and VLDL-cholesterol concentrations, respectively (P < 0.0001). However, low-density-lipoprotein (LDL)-cholesterol concentrations increased by 26% (P < 0.001). Activities of postheparin LPL and HL essentially remained the same. Thus, in patients with primary hypertriglyceridemia, reduction in plasma triglyceride concentrations and increase in LDL-cholesterol concentrations mediated by omega-3 polyunsaturates seem to occur without an increase in LPL or HL activities.
引用
收藏
页码:638 / 642
页数:5
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