SYNTHESIS OF POTENT ANTI-HIV AGENTS - ESTERS OF CASTANOSPERMINE

被引：40

作者：

LIU, PS ^{[1
]}

HOEKSTRA, WJ ^{[1
]}

KING, CHR ^{[1
]}

机构：

[1] MERRELL DOW RES INST,INDIANAPOLIS,IN 46268

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 20期

关键词：

D O I：

10.1016/0040-4039(90)80159-J

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of 6-0- and 7-0-acyl derivatives of the indolizidine alkaloid castanospermine, are described. These compounds are potent inhibitors of the human immunodeficiency virus (HIV) and are potential anti-AIDS agents. © 1990.

引用

页码：2829 / 2832

页数：4

共 13 条

[1] INTERFERENCE WITH HIV-INDUCED SYNCYTIUM FORMATION AND VIRAL INFECTIVITY BY INHIBITORS OF TRIMMING GLUCOSIDASE
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[2] CASTANOSPERMINE, A 1,6,7,8-TETRAHYDROXYOCTAHYDROINDOLIZINE ALKALOID, FROM SEEDS OF CASTANOSPERMUM-AUSTRALE
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[3] AMINOSUGAR DERIVATIVES AS POTENTIAL ANTI-HUMAN IMMUNODEFICIENCY VIRUS AGENTS
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[4] LIU PS, 1989, Patent No. 297534
[5] CASTANOSPERMINE IN ALEXA SPECIES
NASH, RJ
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DRING, JV
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CARTER, D
HEGARTY, MP
BELL, EA
[J]. PHYTOCHEMISTRY, 1988, 27 (05) : 1403 - 1404
[6] CASTANOSPERMINE INHIBITS THE PROCESSING OF THE OLIGOSACCHARIDE PORTION OF THE INFLUENZA VIRAL HEMAGGLUTININ
PAN, YT
HORI, H
SAUL, R
SANFORD, BA
MOLYNEUX, RJ
ELBEIN, AD
[J]. BIOCHEMISTRY, 1983, 22 (16) : 3975 - 3984
[7] CASTANOSPERMINE BLOCKS THE HYPERGLYCEMIC RESPONSE TO CARBOHYDRATES INVIVO - A RESULT OF INTESTINAL DISACCHARIDASE INHIBITION
RHINEHART, BL
ROBINSON, KM
PAYNE, AJ
WHEATLEY, ME
FISHER, JL
LIU, PS
CHENG, W
[J]. LIFE SCIENCES, 1987, 41 (20) : 2325 - 2331
[8] RUPRECHT RM, 1989, J ACQ IMMUN DEF SYND, V2, P149
[9] CASTANOSPERMINE, A TETRAHYDROXYLATED ALKALOID THAT INHIBITS BETA-GLUCOSIDASE AND BETA-GLUCOCEREBROSIDASE
SAUL, R
CHAMBERS, JP
MOLYNEUX, RJ
ELBEIN, AD
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1983, 221 (02) : 593 - 597
[10] ANTIRETROVIRAL ACTIVITY OF CASTANOSPERMINE AND DEOXYNOJIRIMYCIN, SPECIFIC INHIBITORS OF GLYCOPROTEIN PROCESSING
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BOWLIN, TL
LIU, PS
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[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (01) : 206 - 210

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