CERIUM NITRATE-SILVER SULFADIAZINE - SYNERGISM OR ANTAGONISM AS DETERMINED BY MINIMUM INHIBITORY CONCENTRATION

被引：8

作者：

HEGGERS, JP

KO, F

ROBSON, MC

机构：

[1] Section of Plastic and Reconstructive Surgery, University of Chicago Burn Center, IL

来源：

BURNS | 1979年 / 5卷 / 04期

关键词：

D O I：

10.1016/S0305-4179(79)80003-0

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The topical antimicrobial effects of silver sulphadiazine in burn wound therapy are well documented. Clinical studies have recommended the use of cerium nitrate/silver sulphadiazine cream, which apparently decreases mortality rates from burn wound sepsis due to Gram-negative organisms. In vitro assays of minimum inhibitory concentration (MIC) by agar diffusion assay demonstrates that Pseudomonas aeruginosa is more resistant to cerium nitrate (100 per cent at 100 μg) and cerium/silver combination (40 per cent at 100 μg) than to silver sulphadiazine alone (19 per cent at 100 μg). This resistance was further demonstrated at concentrations from 50 to 200 μg. The effect of cerium nitrate upon silver sulphadiazine in combination is apparently one of antagonism rather than synergism. © 1979 John Wright & Sons Ltd.

引用

页码：308 / 311

页数：4

共 9 条

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[2]

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[3]

Heggers, Robson, Gentamicin resistant Pseudomonas aeruginosa with concomitant silver sulfadiazine resistance, 10th Annual Meeting of the American Burn Association, pp. 16-17, (1978)

[4]

Helvig, Oppel, Su, Et al., Cerium silver sulfadiazine vs. silver sulfadiazine: A prospective, randomized study, 10th Annual Meeting of the American Burn Association, pp. 15-16, (1978)

[5]

Holder, Inactivation of silver sulfadiazine by cerium nitrate salts demonstrated by in vitro topical susceptibility testing, 10th Annual Meeting of the American Burn Association, pp. 17-18, (1978)

[6]

Jonsyn, Hartford, McClellan, Blank, Topical treatment of burns with a cerium silver mixture: Experience with 70 patients, 10th Annual Meeting of the American Burn Association, pp. 18-19, (1978)

[7]

Lindberg, Moncrief, Mason, Control of experimental and clinical burn wound sepsis by topical application of sulfamylon compounds, Ann. NY Acad. Sci., 150, (1968)

[8]

McManus, Filip, Mason, Et al., Assessment of in vitro minimal inhibitory concentrations of silver and cerium ions on selected Gram negative burn ward isolates, 10th Annual Meeting of the American Burn Association, (1978)

[9]

Monafo, Ayvazian, Skinner, Control of infection in major burn wounds by cerium nitrate/silver sulfadiazine, Burns, 3, (1977)

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