IMPAIRED ERYTHROCYTE FLUIDITY DURING TREATMENT OF RENAL ANEMIA WITH ERYTHROPOIETIN

被引:28
作者
LINDE, T [1 ]
SANDHAGEN, B [1 ]
DANIELSON, BG [1 ]
WIKSTROM, B [1 ]
机构
[1] UNIV LUND HOSP, DEPT CLIN PHYSIOL, S-22185 LUND, SWEDEN
关键词
BLOOD VISCOSITY; ERYTHROCYTE DEFORMABILITY; ERYTHROPOIETIN; HYPERTENSION; RENAL ANEMIA; UREMIA;
D O I
10.1111/j.1365-2796.1992.tb01246.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Seventeen haemodialysis patients with renal anaemia were treated with recombinant human erythropoietin (rhEPO) and observed for 30 weeks. The viscosity of whole blood and plasma, the erythrocyte aggregation tendency, and the erythrocyte deformability, measured as fluidity, were analysed every second week. All patients responded with increasing haematocrit and whole-blood viscosity. The plasma viscosity and the erythrocyte aggregation tendency were already increased before the start of treatment, and remained unchanged during treatment. The basal erythrocyte fluidity tended to be impaired, although not significantly so. During treatment, significant impairment of fluidity was observed at the beginning of the treatment period. After 24 weeks the fluidity started to increase, and it later reached values observed before the start of treatment. Hence, the quality of the erythrocytes formed during the corrective phase of rhEPO treatment differs in some respects from that of cells formed at a normal production rate. The impaired fluidity might have important implications for the flow resistance in small vessels, and contribute to the development or aggravation of hypertension that is often seen during rhEPO treatment.
引用
收藏
页码:601 / 606
页数:6
相关论文
共 28 条
[1]  
BOHLER T, 1989, CLIN HEMORHEOL, V9, P449
[2]   STUDIES ON ERYTHRO-KINETICS IN INFANCY .13. MEAN LIFE SPAN AND LIFE SPAN FREQUENCY FUNCTION OF RED BLOOD CELLS FORMED DURING FOETAL LIFE [J].
BRATTEBY, LE ;
GARBY, L ;
GROTH, T ;
SCHNEIDER, W ;
WADMAN, B .
ACTA PAEDIATRICA SCANDINAVICA, 1968, 57 (04) :311-+
[3]  
CAIMI G, 1987, CLIN HEMORHEOL, V7, P437
[4]   RED-CELL DEFORMABILITY AND ITS RELEVANCE TO BLOOD-FLOW [J].
CHIEN, S .
ANNUAL REVIEW OF PHYSIOLOGY, 1987, 49 :177-192
[5]  
COTES PM, 1989, Q J MED, V70, P113
[6]   CORRECTION OF THE ANEMIA OF END-STAGE RENAL-DISEASE WITH RECOMBINANT-HUMAN-ERYTHROPOIETIN - RESULTS OF A COMBINED PHASE-I AND PHASE-II CLINICAL-TRIAL [J].
ESCHBACH, JW ;
EGRIE, JC ;
DOWNING, MR ;
BROWNE, JK ;
ADAMSON, JW .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (02) :73-78
[7]   The viscosity of the blood in narrow capillary tubes [J].
Fahraeus, R ;
Lindqvist, T .
AMERICAN JOURNAL OF PHYSIOLOGY, 1931, 96 (03) :562-568
[8]   MEAN RED CELL LIFE OF RATS EXPOSED TO REDUCED BAROMETRIC PRESSURE [J].
FRYERS, GR ;
BERLIN, NI .
AMERICAN JOURNAL OF PHYSIOLOGY, 1952, 171 (02) :465-470
[9]  
GUEGUENDUCHESNE M, 1987, CLIN HEMORHEOL, V7, P418
[10]  
HEIN HJ, 1987, CLIN HEMORHEOL, V7, P430