SPECULATIONS ON THE SUBSTRATE STRUCTURE ACTIVITY RELATIONSHIP (SSAR) OF CYTOCHROME-P450 ENZYMES

被引：216

作者：

SMITH, DA

JONES, BC

机构：

[1] Department of Drug Metabolism, Pfizer Central Research, Sandwich

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 11期

关键词：

D O I：

10.1016/0006-2952(92)90333-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：2089 / 2098

页数：10

共 41 条

[1] SELECTIVITY AND MECHANISM IN THE MICROSOMAL BENZYLIC HYDROXYLATION [J].

AMODEO, R ;

BACIOCCHI, E ;

CRESCENZI, M ;

LANZALUNGA, O .

TETRAHEDRON LETTERS, 1990, 31 (24) :3477-3480

[2]

BERNEHIM LM, 1992, DRUG METAB DISPOS, V20, P241

[3]

BORNHEIM LM, 1992, DRUG METAB DISPOS, V20, P241

[4] ROLE OF P450IID6, THE TARGET OF THE SPARTEINE-DEBRISOQUIN OXIDATION POLYMORPHISM, IN THE METABOLISM OF IMIPRAMINE [J].

BROSEN, K ;

ZEUGIN, T ;

MEYER, UA .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1991, 49 (06) :609-617

[5]

CREWE H K, 1991, British Journal of Clinical Pharmacology, V32, p658P

[6] RELATIONSHIP BETWEEN PHENYTOIN AND TOLBUTAMIDE HYDROXYLATIONS IN HUMAN LIVER-MICROSOMES [J].

DOECKE, CJ ;

VERONESE, ME ;

POND, SM ;

MINERS, JO ;

BIRKETT, DJ ;

SANSOM, LN ;

MCMANUS, ME .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1991, 31 (02) :125-130

[7]

FEIFEL N, 1991, N-S ARCH PHARMACOL S, V343, pR7

[8] THE ROLE OF LIPOPHILICITY IN THE INHIBITION OF POLYMORPHIC CYTOCHROME-P450IID6 OXIDATION BY BETA-BLOCKING-AGENTS INVITRO [J].

FERRARI, S ;

LEEMANN, T ;

DAYER, P .

LIFE SCIENCES, 1991, 48 (23) :2259-2265

[9]

FLEMING CM, 1990, PHARMACOLOGIST, V32, P140

[10]

GUENGERICH FP, 1991, J BIOL CHEM, V266, P10019

← 1 2 3 4 5 →